Hormone Changes

Please see the self or family pattern checklist below.

The liver is thought to both make and excrete hormones and works closely with other organs in the body such as the gallbladder, pancreas, and kidneys.

Hormone changes and formation of kidney or gallstones.

Hormone changes, sinus congestion, adenoid and tonsil problems.

Hormone changes and eyesight.

Serotonin, the digestive tract, pancreas, bile duct, and IBS.

Endometriosis and IBS.

IVF Treatment and Breast Cancer Studies.

Not all women with severe PMS have depression, yet can experience the same level of irritability, anxiety, sadness, weepiness, and physical symptoms as the reported term ‘PMDD’ which suggests that depression is the key factor.  However perhaps MSS (menstrual sadness syndrome) may be a better term as women with severe PMS may experience varying levels of sadness rather than depression and may not be aware of this, and so confusion may occur.

Some psychiatrists may not think a woman has severe PMS if they do not have depression and thus delaying hormone treatment.

I really wish that more was known about the male menopause – the andropause!

Do the hormones in milk or cream when heated in hot drinks give you hot sweats during the menopause?  Or are you a female or male who drinks alot of milk and find that you sweat alot due to hormones in the milk which affects your hormones and pituitary gland that regulates sweating?

Prostaglandins – Hormone Health Network.   Prostaglandins in males and females (The Pituitary).  Prostaglandins, lipids, and cardiovascular system.

Most women in the throes of the menopause (with periods absent for one year) had not heard about the stages of the perimenopause and the signs and symptoms to look out for before their periods stopped.

Most women also do not know the difference between hot flushes and hot flashes and the distress caused by both.  Apparently hot flushes creep up and over, whereas flashes shoot up quickly and take a while to come back down and so causing much distress until the episode finally dies down.

The symptoms of both the perimenopause and the menopause are apparently not unlike premenstrual syndrome, particularly that of sweating and temperature changes.

Hippocrates the famous Greek Physician first described PMS when he noted that some women displayed intermittent agitations, lassitude (weariness), shivering, and heaviness of the head (the encased neurological brain).  Also see Egyptian and Roman connections around the world with Greece and other countries, as well as key words and references on this website.

Rosalind Franklin who was a Chemist and whose work was central to DNA, RNA, and other subjects died of ovarian cancer and although she was involved with x-ray radiation she also has a family history of cancer with gynaecological cancher thought to be perhaps higher amongst Ashkenazi Jews relating to the Holy Roman Empire.

I have included a number of PMS symptoms which you may also recognise with both the perimenopause and the menopause, and is not exhaustive as women present differently and so you might want to do your own research and also compare symptoms to both the perimenopause and the menopause:

  • Headaches and/or migraines (see pure migraines and menstrual migraines).
  • Lumpy painful breasts which may swell several days before a period and then go down before swelling again just before a period.
  • Painful periods with or without heavy bleeding, cramps, dragging feeling, back and pelvic pain.
  • Short or long periods.
  • Regular or irregular periods.
  • Blood clots and shreading.
  • The need to sit down more.
  • Inflammation, swelling, fluid retention, arthritic aches and pains.
  • Extremely irritable and weepy which may be released through crying, release of temper, or orgasm.
  • Feeling intense rage which is difficult to let go off and more likely to hold a grudge during the episode.
  • Great worry, feeling overwhelmed, hopelessness, sadness, and feeling insecure.
  • Anxiety, panic attacks, and agitation.
  • Tendency to withdraw, keep away from others, and isolate oneself.
  • May seek attention or be ‘over the top’ and impulsive.
  • Atopy and sinus problems.
  • Concentration and memory problems.
  • Difficulty focusing on things, thinking straight, and making the right decisions.
  • Increased or decreased appetite and thirst.
  • Fidgeting, sleep disturbance, restless legs, lethargy, temperature changes/shivering.
  • Euphoria or dysphoria, and hysteria.
  • Clumsy, balance problems, problems with manual dexterity – tendency to trip up, bump into things, knock things over, drop things.
  • Sensory  changes such as speech and hearing problems – expressive and receptive.  May slur words, stammer, and have muffled hearing.
  • Sense of great relief when period ends for a short period before a low mood dip which then lifts after a couple of days.
  • Deliberation and dissatisfaction over things and may have a tendency to give things away or throw things away.
  • Low worth and low self-esteem.
  • Poor performance or over performance as a means of fitting in or putting on a brave face.
  • High or low libido.
  • Dryness or excess vaginal lubrication.
  • Bowel and bladder changes – often constipated before menstruation and loose during menstruation.

Latest PMS information for 2016 and 2017

  • Does discovery of ‘severe PMS genes’ offer hope of a cure?, NHS choices, 4/1/17.  This article includes the term PMDD which should be considered with caution as some women with other severe symptoms of PMS such as anxiety and weepiness do not suffer from depression and so PMDD may overshadow their experience and chances for research.  The discovery of the ESC/E(Z) gene research follows that of the 2007 gene research which highlighted the oestrogen receptor alpha gene.
  • Premenstrual Syndrome, Management (Green-top Guideline No.48) suggests that ‘PMS’ encompasses a vast array of psychological symptoms such as depression (dysphoria), anxiety, irritability, loss of confidence, and mood swings.  As well as physical symptoms such as bloatedness and mastalgia.  There is no mention of euphoria and hysteria which is perhaps the forgotten foundation of the history of PMS and the need for chaise lounges and pelvic massage due to dramatic libido issues.

PMS and sleep deprivation – sleep disturbance may cause irritability in anyone, and women with PMS may experience sleep disturbance or not.  If a women leading up to menstruation has sleep disturbance she may wake up irritable or the rising irritability may occur later in the day – does this mean that Cortisol levels are out of balance?

  • Sleep disturbance, irritability, and cortisol.
  • PMS, irritability, and cortisol levels with or without sleep disturbance.
  • PMS genes and the fruit fly (drosophila).  Fruit fly and latex fruit/food syndrome.
  • ESC -E (Z) and the fruit fly/Premenstrual Syndrome.
  • Fruit fly and human genetics.
  • Histamine and the Uterus.
  • Cortisol and the Diurnal Rhythm – hypothalamus, pituitary, and adrenal.
  • Cortisol awakening response, ovarian steroids, and premenstrual syndrome in healthy premenopausal women.

Baby Blues – during and after pregnancy.

No women during such a crucial time should suffer baby blues during or after pregnancy, and knowledge about women with PMS going onto develop baby blues has been noted along with a woman requiring more monitoring without discrimination.  Today psychiatry with its stigma still have the mother and baby units instead of endocrinology/neurology services which is a shame.

I would like to pay a tribute to my Mother, who with the support of my Father, managed to cope with five children despite having hormone and atopy problems which appear not to have had timely intervention.  Other women who have experienced Baby Blues may also report atopic conditions.

Baby Blues with suicide ideation/suicide rates (also see PMS and suicide rates), Bi-polar and Baby Blues, Psychosis and Baby Blues, OCD and Baby Blues, Atopy and Baby Blues.

Symptoms may include:

Tearfulness and weeping, panic attacks, sleep disruption or feeling exhausted despite sleep, nightmares, flashbacks to labour or birth, constant worry, not feeling emotion to your baby, feeling numb and lack of emotion, thoughts of harming your baby, obsessive thoughts or repetitive chanting thoughts or voices, feelings of being overwhelmed, suicidal thoughts and feelings, self-harm, feeling like a bad mother, putting on a brave face to hide how you feel, a desire to escape, a feeling that your family would be better off without you (also see symptoms of PMS and perimenopause/menopause).


  • Melancholic and the four Tempraments: perfectionist, sensitive, introverted, role.
  • New research from America suggests that PMS is linked to post- partum depression: ncbi.nlm.nih.gov/pubmed/23296333
  • PMS link to baby blues, Mailonline 2013.
  • Researchers at Warwick University have found two post-natal depression genes.
  • Norman Lamb talks about son’s mental health struggles – BBC UK Politics 15/3/15. Includes mention of more money spent supporting pregnant women and new mothers, but does not mention PMS which may be the root cause of baby blues.
  • Prenatal and Postnatal Anxiety (also see PMS and Menopause anxiety).
  • ITV Calendar, 5/9/16 – Survey reveals two thirds of women with a postnatal illness have suicidal thoughts.
  • Society for Endocrinology (You & Your Hormones website), 9/1/17.  New guidelines for diagnosis and treatment of thyroid disease during pregnancy and postpartum.
  • FPIE’S Charity – Food Protein Induced Enterocolitis Syndrome (children and adults).

Perhaps more research needs to be done to study and support parents with hormone and atopy, as well as their offspring who may go on to develop the same or similar pattern. 

*****Self or Family Checklist Pattern*****

I have been able to talk to many people with hormone, atopy, and other possible associated conditions and rather than list each person’s pattern as I did before and so sometimes repetitive I have provided a collective list (a cocktail of conditions) and this applies to both males and females – some women report that PMS is not on their mother’s blood line (maternal) but rather that of their Father’s blood line (paternal) so therefore not always passed from mother to daughter:

  • Hayfever, other allergy, asthma, skin problems, and food intolerance or allergy.
  • Premenstrual syndrome (PMS). 
  • Baby blues.
  • Osteopenia/osteoarthritis.
  • Thyroid diseases and vitiligo.
  • Diabetic disorders.
  • Various atopy /allergy including skin disorders and food disorders.
  • Neurological disorders.
  • Polycystic ovaries.
  • Pernicious anaemia/vitamin B12 deficiency/iron deficiency.
  • Cardiovascular disease.
  • Pituitary tumours.
  • Endometriosis.
  • Uterine fibroids.
  • Hormone or protein related cancers.
  • Glaucoma/other hormone eye changes.
  • Mood changes such as dysphoria or euphoria/hysteria.
  • Thrush/candida.
  • Addison’s disease.
  • Raynard’s syndrome.
  • Primary biliary cirrhosis.
  • Gallstones/kidney stones.
  • Addictions/addictive behaviour.
  • Xanthomas.
  • Alzheimers/vascular dementia.
  • Adenomyosis.
  • Fibrous breasts.
  • Histiocytosis.
  • Abusive behaviour and high risk taking.
  • Blood clots and missing protein C.
  • Erectile dysfunction/other sexual dysfunction in both sexes.
  • Blood cancer.
  • Range of learning difference such as aspergers, dyslexia, and dyspraxia.
  • YYX syndrome.
  • Lupus.
  • Multiple sclerosis.
  • ADHD.
  • GORD.
  • M.E, chronic fatigue, fibromyalgia.
  • Panic attacks/panic disorder.
  • Self-harm or harm to others.
  • Shop lifting or poor budgeting skills/impulse buying.
  • Low motivation/low volition/ or excessive energy which may lead to ‘burn out’.
  • Charcot-marie-tooth (peripheral myelin protein-22 PMP-22).  Cleft lip/hare lip.
  • HMNS type 1.
  • Sever’s disease.
  • G6PD deficiency.
  • Various mental health labels such as bi-polar, schizophrenia and psychosis.
  • Schmidt’s syndrome.
  • Colitis and crohn’s disease. 
  • Social phobia.
  • Eating disorders and body dysmorphia.
  • Under developed breasts.
  • Partial alpha 1 antitrypsin deficiency (Pi MZ).
  • Infertility.
  • Early sexualisation in boys and girls with feeling of wanting to deal with sex drive (chronic masturbation).  May also have atopy.

Mental illness and challenging behaviour in minors who have parents with endocrine disorders, neurological disorders, and atopy problems.

Endocrine Disorders and induced dementia.

Dementia genes.

Pms and Baby Blues.

PMS/Menopause and oestrogen drop causing night sweats.

Hormone and Protein related cancers.

Are the PMS genes and the Autism genes related?

Please note that more conditions may be added over time.

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